Massachusetts General Hospital

Cancer Center

Massachusetts General Hospital Cancer Center is committed to eradicating cancer and is fueled by scientific investigation conducted as part of the largest hospital-based research program in the United States.

Cardiovascular Research Center

The Cardiovascular Research Center (CVRC) at Massachusetts General Hospital was founded in 1990 to bridge the gap between the science of heart disease and the practice of cardiovascular medicine.

CCIB

The Massachusetts General Hospital Center for Computational and Integrative Biology is an affiliation of faculty drawn together by a common interest in the study of biology through methods engaging a broader scale of inquiry than the existing standard.

Center for Human Genetic Research

The Massachusetts General Hospital Center for Human Genetic Research is a multidisciplinary crossdepartmental center with the central mission of facilitating the genetic research cycle.

Center for Regenerative Medicine

The Center for Regenerative Medicine is dedicated to understanding how tissues are formed and may be repaired in settings of injury and disease.

Center for Reproductive Biology

The Vincent Center for Reproductive Biology consists of basic and clinical scientists whose primary research emphasis includes infertility, aging and cancer as they pertain to the ovary and uterus. The center provides an optimal environment for individuals who are interested in integrating clinical and basic sciences and have a strong desire to pursue a career in academic research.

Center for Systems Biology

The goal of the Massachusetts General Hospital Center for Systems Biology is to analyze, at a systems level, how biological molecules, proteins and cells interact in both healthy and diseased states.

Center for the Study of IBD

CSIBD is a Research Center focused on IBD-oriented research at Massachusetts General Hospital and affiliated institutions sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases.

Center for Translational Pain Research

The Center for Translational Pain Research strives to improve the clinical management of patients experiencing acute, chronic, and cancer pain conditions by using a multidisciplinary and mechanism-based research approach to clinical pain management together with basic science pain research.

Cutaneous Biology Research Center

To achieve that goal the CBRC maintains an environment conducive to collaboration with industrial partners to disseminate the fruits of fundamental research from the CBRC.

Immunology & Inflammatory Diseases

Mass General’s CIID is a multidisciplinary research center focused on basic mechanisms of immune-mediated inflammatory diseases.

MIND / Neurology Research

The Mass General Institute for Neurodegenerative Disease (MIND) is poised to change the future for people with Alzheimer’s, ALS (Lou Gehrig’s), Huntington’s, and Parkinson’s diseases.

Wellman Center for Photomedicine

The Wellman Center for Photomedicine at Massachusetts General Hospital investigates the effects of light on human biology and develops light-mediated, minimally invasive diagnostic and therapeutic technologies.

Advancing Understanding of Mechanisms of Hepatitis-Related Liver Disease – Chung Laboratory

Our laboratory has been involved in uncovering the mechanisms by which hepatitis viruses, particularly hepatitis C virus, persist in the liver and cause liver damage. Our projects will advance care of patients with liver diseases through enhanced understanding of what causes chronic viral infection, and will help to identify novel drugs to help treat patients who have been nonresponders or ineligible to receive current treatments.nonresponders or ineligible to receive current treatments.

Albers Laboratory (MIND) - Mark W. Albers, MD, PhD

The Albers’s Laboratory uses the olfactory system of mice and humans to elucidate early pathologic events of neurodegeneration.

Alexander G. Marneros, M.D., Ph.D.

Alexander G. Marneros, MD/PhD Assistant Professor, Department of Dermatology, Harvard Medical School Assistant in Dermatology (Attending), Massachusetts General Hospital

Allen Steere, MD

The Steere Laboratory does translational studies using samples from patients with Lyme arthritis or rheumatoid arthritis to delineate mechanisms involved in the pathogenesis of these diseases, to identify biomarkers of disease activity, and to develop diagnostic tests.

Andrew D. Luster, MD, PhD

The Luster Laboratory investigates chemokines, lipid chemoattractants and their receptors in normal physiology and disease.

Andrew Tager, MD

The Tager Laboratory investigates (1) pulmonary and dermal fibrosis, focusing on the roles lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), and (2) HIV immunopathogenesis, using a novel mouse model of HIV infection.

Arlotta Lab

The genetic programs that control the differentiation of distinct types of neurons in the brain are still largely unknown. In our lab we address this issue in the mammalian cerebral cortex and our main interest focuses on understanding and investigating the molecular pathways that direct the early specification of progenitors to generate distinct types of projection neurons during development. We specifically focus on the early signals that induce differentiation of corticospinal neurons, a clinically relevant neuronal target population that in humans selectively degenerates in ALS (Lou Gehrig’s disease), Hereditary Spastic Paraplegia (HSP), Primary Lateral Sclerosis (PLS), and that is permanently injured in spinal cord injury.

Badizadegan Lab

Bardeesy Lab

Research topics include: pancreatic ductal adenocarcinoma

Behavioral Medicine Service

The Behavioral Medicine Services include clinical, research, and training activities that focus on the intersection of psychology and health.

Benjamin Medoff, MD

The Medoff Laboratory studies the pathogenesis of pulmonary inflammation, specifically the role of T cells in mediating inflammatory lung diseases.

Bernards Lab

Research topics include: Neurofibromatosis-1 (NF1)

Bernstein Lab

Our laboratory applies high-throughput sequencing-based technologies to characterize chromatin structure genome-wide in human and mouse.

Bhan Lab

Mucosal Immunology and Inflammatory Bowel Disease

Bioengineering Laboratory

The Bioengineering Laboratory, under the direction of Guoan Li, PhD, continues its tradition of innovation in the area of joint engineering and biomechanics.

Biomaterials Research Laboratory

This Laboratory provides unique opportunities for scientists, residents, fellows and staff and is an integral part of the future of Orthopaedic Research at Mass General.

Body Dysmorphic Disorder Clinic & Research Unit

The Research Unit currently focuses on studies regarding the treatment of BDD as well as the factors that contribute to the development and maintenance of BDD.

Bone Marrow Transplant Clinical Research

The clinical mission of the Bone Marrow Transplant Clinical Research Lab is to provide a comprehensive range of transplant-related services to patients with hematologic malignancies and other potentially life-threatening blood dyscrasias. Its research mission is to develop novel methods of allogeneic stem cell transplantation to maximize the separation of graft versus host disease (GVHD) and graft versus tumor (GVT) effect in both the HLA-matched and mismatched settings.

Boucher Lab

As part of the Edwin L. Steele Laboratory for Tumor Biology, the Boucher Laboratory analyzes delivery of oncolytic viruses and large therapeutic agents in tumors and tumor cell migration and metastasis.

Brack Lab

Our lab interests lie at the interface between adult stem cell biology and tissue regeneration. We focus on the molecular pathways that control cell fate decisions of the adult muscle stem cell (the satellite cell) to effectively regenerate adult skeletal muscle.

Brack Lab

Our lab interests lie at the interface between adult stem cell biology and tissue regeneration. We focus on the molecular pathways that control cell fate decisions of the adult muscle stem cell (the satellite cell) to effectively regenerate adult skeletal muscle.

Breast Cancer Clinical Research

Our program is on the forefront of investigation to find better therapies, improve diagnostics, and develop less invasive, breast-sparing surgical techniques for the treatment of breast cancer.

Bruce A. Morgan, Ph.D

Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital

Brugge research

Dr. Brugge is an active clinical consultant in gastroenterology and gastrointestinal endoscopy, focusing on patients with complex pancreatic diseases. His research has focused on the early diagnosis of pancreatic cancer, developing a variety of endoscopic techniques to aspirate malignant and pre-malignant lesions of the pancreas.

Cardiac Anesthesia Lab

Research within the Cardiac Anesthesia Lab at Massachusetts General Hospital advances the evolving field of cardiac anesthesiology and improves outcomes for both adult and pediatric patients.

Cardiac MR PET CT Lab

The Cardiac MR PET CT Lab at Massachusetts General Hospital has built a tremendous expertise in all aspects of cardiovascular imaging research over the last years.

Cardiac Surgery Lab

Cardiac surgery research at the Massachusetts General Hospital Heart Center offers patients the most promising therapies based on the latest scientific evidence.

Cardiovascular Clinical Research Lab

The Cardiovascular Clinical Research Lab seeks to improve clinical diagnosis and treatment of cardiovascular diseases.

Cartilage Biology and Orthopaedic Oncology Laboratories

The Orthopaedic Oncology Laboratory seek factors that may serve as predictors of metastasis in malignant bone and soft tissue tumors both by molecular and biochemical studies and by flow cytometric analyses of DNA ploidy and cell cycle parameters.

Cash, Sydney S., PhD - Cortical Physiology Laboratory

We combine microelectrode and macroelectrode recording and computing techniques to study brain activity, mechanisms for brain machine interface, and the neurophysiology of epilepsy.

Cellular & Molecular Radiation Oncology Laboratory

Working at the cellular and molecular levels, our studies cover a range of topics, including mechanisms of cell death, DNA damage induction and repair processes, bystander effects, and cancer genetics.

Center for Addiction Medicine

The MGH-Harvard Center for Addiction Medicine delivers clinical evaluation, consultation, and study-related clinical care in a multidisciplinary setting.

Center for Anxiety & Traumatic Stress Disorders

The mission of the Center for Anxiety and Traumatic Stress Disorders (CATSD) is to conduct state-of-the-art research aimed at improving the standard of care for people suffering from anxiety disorders.

Center for Applied Clinical Investigation

The Center for Applied Clinical Investigation (CACI) is a training and research center where scientific rigor is used to examine clinical practice and to determine risks and outcomes associated with the variables that comprise patient care.

Center for Cancer Risk Assessment Clinical Research

The Center for Cancer Risk Assessment (CCRA) is devoted to the integration of molecular genetics and the clinical study of cancer predisposition. The Center has both laboratory and clinical components.

Chan_Research_1375

Our research is focused on traditional, molecular, and genetic epidemiology of digestive diseases, including colorectal cancer, inflammatory bowel disease, and gastrointestinal bleeding.

Chemical Genomics of Neuropsychiatric & Neurological Disease - Haggarty Laboratory

The Chemical Genomics Laboratory (CGL) is unraveling the molecular mechanisms underlying neuroplasticity to develop novel, targeted therapeutics for the treatment of neuropsychiatric and neurological diseases.

Cheng Lab

Currently, our projects, sponsored by the National Cancer Institute, involve human prostate, breast cancer and brain tumors.

Chung Lab

The main research interest of the Chung Laboratory has been studies of the biology of hepatitis C virus infection, the leading cause of chronic viral liver disease in the U.S.

Chung Lab

The overall goal of the Chung Laboratory is to better elucidate the genetic events in gastrointestinal tumorigenesis.

Classon Lab

Research topics include: the role of the pRB pathway and the pRB family of proteins (pRB, p107 and p130) in tumorigenesis

Clinical Trials Network & Institute (CTNI)

The MGH Psychiatry CTNI is part of the MGH Psychiatry Department, one of the leading academic research programs in the world - with over $35 million in research programs last year alone. Our department has extensive experience over the past 25 years in industry-sponsored multi-center clinical trials.

Clinical trials of antiviral therapy for chronic viral hepatitis - Dienstag

Dr. Dienstag is an experienced clinical investigator in the area of viral hepatitis (trials of antiviral therapies for chronic hepatitis B and C). Between 2000 and 2010, he was the site-PI of a national trial of maintenance antiviral therapy for patients refractory to treatment for chronic hepatitis C, the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) Trial.

Clinical trials of antiviral therapy for chronic viral hepatitis - Dienstag Clinical Research

Dr. Dienstag is an experienced clinical investigator in the area of viral hepatitis (trials of antiviral therapies for chronic hepatitis B and C). Between 2000 and 2010, he was the site-PI of a national trial of maintenance antiviral therapy for patients refractory to treatment for chronic hepatitis C, the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) Trial.

Cognitive Behavior Therapy (CBT)

The mission of the Cognitive Behavior Therapy (CBT) Program is to inform and educate healthcare professionals, students, and the general public about CBT, further CBT research, and provide advanced clinical care to patients in the context of CBT.

Colvin Lab

Dr. Colvin's laboratory is now primarily focused on the role of T regulatory cells (Foxp3+) in spontaneous acceptance of renal allografts in mice.

Cost Effectiveness of Preventing AIDS Complications (CEPAC)

Cost Effectiveness of Preventing AIDS Complications (CEPAC) is an HIV clinical modeling team that compares the effectiveness of different HIV treatment strategies, in collaboration with investigators around the world.

Cowan Lab

Our research is focused on understanding the contribution of environmental and genetic factors in the development of disease. We are building in vitro models using human embryonic stem cells, in which genetic and developmental aspects of the disease can be controlled.

Craniofacial Developmental Biology Laboratory

Advances in clinical treatment of congenital craniofacial malformations require improved understanding of the developmental genetic basis of facial morphogenesis. Our goal in the Craniofacial Developmental Biology Laboratory is to investigate fundamental genetic regulation of facial development, with a focus on translating basic science discoveries to clinical advances.

Cusack Lab

Research topics include: overcoming anti-apoptotic responses to chemotherapy and irradiation

Davidson Lab

Our lab uses zebrafish as a genetic model system to understand how kidney cells are formed during embryonic development. We are currently using genetic screens, morpholino-mediated gene knockdown, and the generation of inducible transgenic lines to unravel the transcriptional networks governing renal development.

Depression Clinical & Research Program (DCRP)

The DCRP is considered one of the leading centers for the study of Unipolar Depressive Disorders worldwide.

Di Tomaso Lab

Research topics include: vaascular physiology of neurofibromatosis type 2 tumors

Diabetes Research | David Altshuler, MD PhD

The Alshuler lab focuses on studies of human genome sequence variation as a route to understanding the inherited basis of common human diseases, with a major focus on type 2 diabetes.

Diabetes Research Center

The MGH Diabetes Clinical Research Center, currently in its 20th year, focuses on the development and evaluation of innovative therapies for Type 1 and Type 2 diabetes and their complications.

Diabetes Research Center - Clinical and Translational Research

For over two decades, the Mass General Diabetes Clinical Research Center has developed and evaluated innovative therapies for Type 1 and Type 2 diabetes.

Diabetes Unit Type 2 Diabetes Laboratory

The Type 2 Diabetes Laboratory focuses on studies relating to insulin resistance in type 2 diabetic patients.

Dighe Lab

Research and development of expert system software for pathology interpretations.

Division of Nephrology Research Program

The Division of Nephrology's research programs are directed towards the elucidation of basic cellular mechanisms and the causes, management and potential therapies of kidney disease.

Division of Research in Emergency Medicine

The Division of Research in the Department of Emergency Medicine at Massachusetts General Hospital pursues a highly active research agenda.

Donald Bloch, MD

The Bloch Laboratory investigates the putative infectious agent or agents that initiate autoimmune disease.

Dr. Cosmas Giallourakis

We study genetics of intestinal diseases.

Dr. J. Rodrigo Mora Laboratory

Understanding the impact of leukocyte trafficking in gastrointestinal and systemic immunity in health and disease

Dr. Snapper's Lab

Our laboratory is broadly interested in cell signaling pathways that regulate immune cells and epithelial cells in health and disease and the role of host: microbial cytoskeletal interactions in microbial pathogenesis.

Dryja Lab

Ophthalmic pathology, hereditary diseases of the eye, new therapies for eye disease

Duda Lab

Research topics include: solid tumor cellular biology; bone marrow-derived cells in tumor angiogenesis and cancer progression.

Dyson Lab

Research topics include: E2F - and pRB-; tumorigenesis

Eating Disorders Clinical & Research Program

Our mission is to provide and to model excellent clinical care for patients and families affected by an eating disorder. The MGH Eating Disorders Clinical and Research Program is also committed to the generation and dissemination of knowledge for understanding, preventing, and treating eating disorders through clinical consultation, professional training, and research.

Edwin L. Steele Laboratory for Tumor Biology

The Edwin L. Steele Laboratory is committed to improving the prevention, detection and treatment of cancer in patients through a better understanding of tumor pathophysiology and host-tumor interactions.

Ellisen Lab

Research topics include: P53 and human tumorigenesis; breast cancer

Emergency Medicine Network

The Emergency Medicine Network's (EMNet) mission is to advance public health objectives through multicenter, emergency department-based research.

Endocrine Cancers Clinical Research

The Program in Endocrine Malignancies is dedicated to the diagnosis and therapy of benign and malignant tumors of the endocrine glands. The physicians affiliated with this center have expertise in the diagnosis and treatment of benign and malignant tumors of the thyroid, parathyroid, and adrenal glands as well as the tumors of the endocrine pancreas.

Endocrine Unit Research

Research in the Endocrine Unit focuses on metabolic bone diseases and mineral metabolism and ranges from trials of novel therapies for osteoporosis to use of genetically altered mice and cell biology to understand the factors that influence calcium and phosphate metabolism.

Endocrine Unit: Bastepe Laboratory

The Bastepe Laboratory investigates the role of the GNAS locus and its gene products in physiology and disease pathogenesis.

Endocrine Unit: Bergwitz Laboratory

Our research interest focuses on inborn errors of phosphate metabolism and the study of the metabolic and endocrine effects of phosphate using high throughput RNAi screening technology and Drosophila genetics.

Endocrine Unit: Demay Laboratory

The Demay Laboratory is focused on understanding the role of the Vitamin D receptor in hair follicle biology and actions of this receptor that are required to prevent alopecia and promote skin homeostasis. In addition, investigations are being performed to examine the role of phosphate in endochondral bone formation and in the prevention of rickets.

Endocrine Unit: Divieti Pajevic Laboratory

The Divieti Pajevic Laboratory of the Endocrine Unit investigates the complex interactions involved in bone metabolism.

Endocrine Unit: Gori Laboratory

The Gori Laboratory Studies bone development and metabolism in animal models.

Endocrine Unit: Kobayashi Laboratory

The Kobayashi Laboratory investigates the genetics of skeletal development.

Endocrine Unit: Kronenberg Laboratory

The Kronenberg Laboratory uses genetically altered mice to understand the roles of the PTH/PTHrP receptor in bone development, physiology, support of hematopoiesis, and disease.

Endocrine Unit: Mannstadt Laboratory

Research in the Mannstadt Laboratory focuses on diseases of the parathyroid glands.

Endocrine Unit: Shimada Laboratory

The Shimada Laboratory of the Endocrine Unit investigates the complex interactions involved in bone development and remodeling.

Engelman Lab

Research topics include: lung cancer; targeted therapies; molecular fingerprinting

Epidemiologic and Translational Research in Digestive Diseases - Dr. Andrew Chan

Our research is focused on traditional, molecular, and genetic epidemiology of digestive diseases, including colorectal cancer, inflammatory bowel disease, and gastrointestinal bleeding.

Ethan A. Lerner, M.D., Ph.D.

Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital

Fernandez-Del Castillo Lab

The principal focus of our research is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic cancer, specifically the contribution of developmental genes.

Fisher Lab

Our group studies cell death/proliferation signals in relation to development and disease, particularly in cancer of pigment cells (melanoma) and tumors of childhood. We attempt to understand critical modes of cell homeostasis with a goal of molecular targeted therapy as well as prevention of melanoma and other human cancers

Frosch Lab

My laboratory is interested in the development and characterization of animal models of human neurodegenerative diseases, particularly Cerebral amyloid angiopathy (CAA), Alzheimer and Parkinson diseases.

Fukumura Lab

Research topics include: nitric oxide; angiogenesis; tumor microcirculation; intravital microscopy; tumor microenvironment

Garkavtsev Lab

Research topics include: mechanisms governing the development of brain tumors

Gastrointestinal Cancers Clinical Research

The Tucker Gosnell Center for Gastrointestinal Cancers is the first center of excellence in the Harvard system that focuses on integrated multidisciplinary care and research for hepatic and biliary malignancies.

Geijsen Lab

My laboratory focuses on understanding the biology of pluripotent stem cells. We aim to develop novel human models for development and disease, to ultimately enable the application of cell- or tissue-based therapies for the treatment of degenerative disease.

Genitourinary Cancers Clinical Research

The clinical research program of the Claire and John Bertucci Center for Genitourinary Cancers is a multidisciplinary effort to understand cancer biology, discover novel agents and improve treatment outcomes for patients with genitourinary malignancies including cancers of the prostate, bladder and kidney.

Geriatric Education Center Grant

Chronic Care Educational Resource Training Project, Teaching Trainees how to Better Communicate with Older Adults Living with Chronic Disease

GI Cancers – Daniel C. Chung Laboratory

Our laboratory seeks to gain new insights into the molecular pathogenesis of tumors of the GI tract. Our particular areas of interest are colon cancer, neuroendocrine tumors, angiogenesis, hypoxia, hereditary cancers, and genetic instability. We seek to identify molecular targets that can ultimately guide therapeutic strategies.

Giallourakis Laboratory

We study genetics of intestinal diseases.

Gian Paolo Dotto, M.D., Ph.D.

G. Paolo, Dotto, MD, PhD Professor Massachusetts General Hospital Cutaneous Biology Research Center Building 149, 13th Street Charlestown, MA 02129 Tel: (617) 724-9538 Fax: (617) 726-9572 Email: gdotto@partners.org

Gilbertson Lab

Our laboratory develops information systems and robots to support the diagnostic laboratory, the diagnostic process and the communications from the lab to the clinicians, researchers and patients.

Grabowski Lab

Research topics include: endothelial cell function; imaging platelet thrombosis; blood rheology and thrombosis; hemolytic uremic syndrome

Greenberg, Steven M. - Cerebral Amyloid Angiopathy Research Lab

Research on the pathogenesis, diagnosis and treatment of cerebral amyloid angiopathy (CAA), a cause of cerebral hemorrhage in the elderly.

Gynecologic Cancer Clinical Research

The Gillette Center for Gynecologic Oncology has become one of the nation's outstanding centers for clinical research in gynecologic malignancy. The center has had a strong leadership role at every level of development of therapies for women's cancers, from preclinical drug development, to Phase I and II trials, to Phase III cooperative clinical trials.

Haber Lab

Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer

Haigis Lab

Our primary approach is to genetically manipulate Ras signaling pathways both in vivo, in the mouse colonic epithelium, and in vitro, in human colorectal cancer cells. These complementary experimental systems are integrated through cell biology, biochemistry, and systems biology.

Harris Orthopaedic Biomechanics and Biomaterials Laboratory (HOBBL)

The Harris Orthopaedic Biomechanics and Biomaterials Laboratory (HOBBL) is under the co-direction of Orthun Muratoglu, PhD, and Henrik Malchau, MD, PhD. Members of this laboratory have contributed to the field of Adult Reconstructive Surgery for over four decades.

Hart Lab

Research topics include: modeling neurodegenerative disease in C. elegans; notch signaling in the adult nervous system; osmotic stress response and aging; quiescence and sensory signaling; lipid homeostasis

Harvard Program in Refugee Trauma

The Harvard Program in Refugee Trauma has spent 25 years caring for the health and mental needs of survivors of mass violence and torture through a combined practice of clinical experience and medical research.

Harvard Reproductive Endocrine Sciences Center

Supported by the National Institute of Child Health and Human Development (NICHD) for close to two decades, the Harvard Reproductive Endocrine Sciences Center builds and sustains the careers of investigators interested in the field of reproductive science.

Head & Neck Cancers Clinical Research

The Center for Head and Neck Cancers is a longstanding multidisciplinary clinical and scientific program that arose from a foundation established by world-renowned clinicians at Massachusetts General Hospital (MGH) and the Massachusetts Eye & Ear Infirmary (MEEI).

Held Lab

Research topics include: apoptosis; DNA damage and repair; oxidative stress; radiation-induced bystander effects; heavy ion radiation biology

Hematologic Malignancies Clinical Research

The Hematologic Malignancies Program encompasses research regarding leukemia, lymphoma and multiple myeloma, incorporating a substantial commitment to the understanding and use of stem cells in these diseases. It is closely integrated with the Bone Marrow Transplant Program, sharing commitment, faculty and research efforts.

Higgins Lab

I study the dynamics of human pathophysiologic processes by developing mathematical descriptions of complex human disease phenotypes and how they change over time.

Hochedlinger Lab

Research topics include: pluripotency and nuclear reprogramming

Hochedlinger Lab

Our lab tries to understand the role stem cells play in normal development and disease.

Hock Lab

Research topics include: transcription factors in blood development and leukemia

Hock Lab

Our laboratory is interested in the transcriptional regulation of normal blood cell development and leukemia.

Hodin Lab

The major focus of the laboratory is to unravel the molecular mechanisms that underlie the processes of growth and differentiation within intestinal epithelia.

Huang Lab

Research topics include: spontaneous tumors and their isograft models; histopathology; pathophysiology

Iafrate Lab

We have established a broad cancer genotyping platform, termed SNAPSHOT, which detects recurrent mutations in DNA from archived pathology specimens. This platform is allowing for a molecular stratification of cancer patients, and in some cases allowing for placement of patients into trials of novel agents that target specific mutated gene products.

Iliopoulos Lab

Research topics include; biology of tumor suppressor genes and tumor angiogenesis

Immunobiology Laboratory Type 1 Diabetes Research

The Mass General Immunobiology Laboratory conducts basic and translational research focused on discovering novel treatments for autoimmune diseases, with a specific focus on type 1 diabetes.

International Division

The mission of the Division of International Psychiatry at MGH is to make clinical, educational and research contributions to world mental health and to help reduce the global burden of disease by learning from our neighbors and by contributing what we know to better relieve the suffering from mental illnesses around the world.

Intestinal epithelial cell homeostasis – Mizoguchi Lab

Our Main Research Interests: Intestinal epithelial cell homeostasis under normal and inflammatory conditions; Role of epithelial cells in innate and acquired immune response; Cellular and molecular biology of mucosal immunity.

Jain Lab

Research topics include: tumor microenvironment; angiogenesis and lymphangiogenesis; metastasis; in vivo imaging; translational research; drug delivery, nanotechnology, mathematical modeling

James Moon, PhD

The Moon Laboratory focuses on basic issues of CD4+ T cell tolerance studied by directly tracking antigen-specific populations in mouse and human models.

Janice L. Brissette, Ph.D.

Associate Professor, Harvard Medical School Associate Biologist, Massachusetts General Hospital

Jin Mo Park , Ph.D.

Assistant Professor of Dermatology Harvard Medical School Assistant Biologist (Dermatology) Massachusetts General Hospital

Joseph El Khoury, MD

The El Khoury Laboratory investigates the role of the innate immune system in neurodegeneration, inflammation and host defense against infectious pathogens.

Joung Laboratory

Our laboratory has developed robust protein engineering methods for constructing artificial "designer" DNA-binding domains.

Kaplan_Lab

At the MGH Weight Center, we believe that treatments for obesity that are safe and effective will be discovered only through ongoing research to find the answers to these and other questions.

Katia Georgopoulos, Ph.D.

Katia Georgopoulos, Ph.D. Professor of Dermatology Harvard Medical School Biologist (Dermatology) Massachusetts General Hospital

Kovacs Lab, Neurobiology of Disease Laboratory at MIND

Molecular research of neurodegeneration in Alzheimer’s disease (AD) focused on identifying cellular pathways regulating the generation of the toxic beta-amyloid protein (Abeta).

Kristin White, Ph.D.

Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital

Kuter Lab

Research topics include: thrombopoietin; thrombocythemia

Laboratory for Lipid Medicine and Technology

The Laboratory for Lipid Medicine and Technology is dedicated to generating knowledge on the roles of lipids in human biology and their impact on human health, as well as developing novel medicine and technologies for disease management and health promotion.

Laboratory for Musculoskeletal Research and Innovation

Healthy bones, joints and skeletal tissues are essential for daily living, to maintain fitness, to enable locomotion, and to maintain independence. While generally robust, the musculoskeletal system is susceptible to disease and injury often with debilitating consequences and wide-reaching impact.

Laboratory of Gastrointestinal Epithelial Biology

The Laboratory of Gastrointestinal Epithelial Biology works to unravel the molecular mechanisms that underlie the processes of growth and differentiation within intestinal epithelia, focusing on gut mucosal defense and how the host interacts with the intestinal microbiota.

Laboratory of Molecular Endocrinology

The Laboratory of Molecular Endocrinology conducts basic research to discover the causes of diabetes and potential cures for the disease.

Laboratory of Orthopaedic Biochemistry and Osteoarthritis Therapy

The overall mission of this laboratory is to understand the molecular mechanisms underlying the loss of extracellular matrix function that occurs in cartilage during degenerative arthritis.

Lamont Lab

Research topics include: clinical epidemiology and health services research in cancer

Langenau Lab

Self-renewal is responsible for the indefinite replicative potential found in malignant cells and is likely found in residual cell populations that evade conventional therapy and lead to relapse. Uncovering downstream molecular pathways that regulate self-renewal will be integral to identifying novel drugs for the treatment of cancer.

Lauer Laboratory – Immunology of Viral Infections in Humans

Understanding the human immune response against viruses, with a focus on T-cell responses targeting human hepatotropic viruses (Hepatitis C Virus (HCV), Hepatitis B Virus (HBV), HCV/HIV co-infection). Establishing the groundwork for rational design of antiviral vaccines and immunotherapies.

Laurel A. Raftery, Ph.D.

Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital

Lipid Metabolism Unit

Research in the Lipid Metabolism Unit focuses on the role of lipids and lipoproteins in atherosclerosis.

Louis Lab

Research topics: glioma, glioblastoma, molecular genetics, molecular pathology, therapeutics

Maheswaran Lab

Research topics include: tumorigenesis; breast cancer; cancer genetics

Masa Osawa, PhD

Assistant Professor of Dermatology, Harvard Medical School. Assistant Biologist, Cutaneous Biology Research Center Center for Regenerative Medicine, Massachusetts General Hospital

Mass General Epilepsy Research Laboratory, Daniel Hoch, MD, PhD, and Sydney S. Cash, MD, PhD

The Mass General Epilepsy Research Laboratory researches the anatomical, biochemical and physiological consequences of abnormal neuronal activity.

MassGeneral Institute for Neurodegenerative Disease (MIND)

The MassGeneral Institute for Neurodegenerative Disease (MIND) is poised to change the future for people with Alzheimer’s, ALS (Lou Gehrig’s), Huntington’s, Parkinson’s and other neurodegenerative diseases. The Institute was established to accelerate research discoveries that will lead to treatment and cures – sooner, rather than later.

McClatchey

Research topics include: neurofibromatosis type 2; epidermal growth factor receptor (EGFR); cortical cytoskeleton; Ezrin, radixin, moesin (ERM proteins); polarity

Melanoma Clinical Research

The Center for Melanoma draws upon the specialized expertise of physicians and researchers from the Departments of Dermatology and Radiation Oncology, and the Divisions of Surgical Oncology, Transplant Surgery, Hematology and Oncology, and Dermatopathology.

Michaelson Lab

Development of databases on several cancers, testing systems, and various analyses.

Mizoguchi Lab

My laboratory has focused on the studies to provide rationales to develop novel therapeutic strategies for IBD patients by utilizing genetically engineered experimental models of this disorder.

Mohapatra Lab

Current research is focused on the development and application of DNA-based microarray CGH (array CGH) to map DNA copy number aberrations in different genetic subgroups of brain tumors.

Mostoslavsky Lab

Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair

Mucosal Immunology, Microbial Defense and Inflammatory Bowel Diseases - Reinecker Laboratory

We uncover the genetic basis and molecular mechanisms of microbial recognition and immune regulation in the digestive tract.

Munn Lab

Research topics include: leukocyte mechanics and tumor physiology

Murat Bastepe, MD, PhD

Our broad goal is to understand the role of the complex GNAS locus in physiology and in disease.

Music in Medicine Research Group

The mission of the Music in Medicine Research Group is to discover how music can impact patients, relatives and physicians with clinical trials as well as bench work research conducted according to the highest scientific standards.

Naar Lab

Research topics include: molecular mechanisms of gene regulation; the function of co-activators and co-repressors in mediating the action of transcription regulators

Natural Orifice Translumenal Endoscopic Surgery (NOTES) Laboratory

The Natural Orifice Translumenal Endoscopic Surgery (NOTES) Laboratory develops innovative minimally invasive techniques using the body’s natural orifices to perform surgeries.

Neuroendocrine Clinical Research Program

Learn more about clinical research in the Neuroendocrine Unit at Mass General.

Neuroendocrine Malignancies Clinical Research

The Neuroendocrine Center is one of the premier multidisciplinary clinical and research programs in neuroendocrinology and pituitary tumors in the USA. A recognized international referral center, the Neuroendocrine Center incorporates multidisciplinary expertise from Neuroendocrinology, Neurosurgery, Neurology, Radiation Oncology and Psychiatry.

Neuroendocrine Research Laboratory

Learn more about basic research the the Neuroendocrine Unit at Mass General.

Neuroenteric Research Laboratory - Dr. Braden Kuo

The laboratory is focused upon clinical and translational research in GI Motility and Visceral Pain Syndromes such as GERD, gastroparesis, constipation and irritable bowel syndrome.

Neurology Clinical Trials Unit

The Neurology Clinical Trials Unit (NCTU) at Masschusetts General Hospital is an Academic Contracted Organization (ACRO) experienced in developing and conducting multicenter clinical trials in neurological diseases.

Neuro-Oncology Clinical Research

The Stephen E. and Catherine Pappas Center for Neuro-Oncology is a national leader in clinical research and the development of experimental therapeutics for adult malignant brain tumors.

Nir Hacohen, PhD

The Hacohen Laboratory investigates the initiation of immune responses, the sensing of pathogens, host-pathogen biology and the development of approaches to discover and model genetic and biochemical networks.

NMR Surgical Laboratory

The Mass General Nuclear Magnetic Resonance Surgical Laboratory investigates biomedical problems related to mechanisms underlying significant medical paradigms, including neoplasia, injury, inflammation, infection and stroke rehabilitation.

Nutt Lab

The primary research interests of our laboratory are the biological and clinical implications of brain tumor heterogeneity.

OCD Clinic & Research Unit

The OCD Clinic & Research Unit at the Massachusetts General Hospital is one of the oldest and most respected outpatient OCD and OC Spectrum clinics in the country.

Ongoing Research

The Geriatric Research Unit at Mass General is largely involved in physiological research. Our research is mainly endocrine in nature with two major ongoing projects that are focused on glucose intolerance and muscle changes with aging.

Outcomes Research Center

Research at the Outcomes Research Center at Massachusetts General Hospital focuses on evaluating the impact of cancer and its treatment on patients, helping patients make better, more informed treatment decisions, and assessing and improving patient-centered cancer care.

Padera Lab

Research topics include: the pathophysiology of tumor associated lymphatic vessels and lymphatic metastasis

Pathology Research Center - Immunopathology Research Unit

Translational Research in Immunology and Transplantation [Image: dendritic cells (green) and foxp3+ cells (red) in an accepted mouse kidney graft]

Pathology Research Center - Molecular Pathology Unit

Basic and translational research with an emphasis on cancer biology

Pediatric Cancer Clinical Research

The Center for Pediatric Hematology and Oncology is actively participating in clinical trials and translational research. A significant number of our clinical trials are through collaborative efforts with the Children's Oncology Group (COG), the Pediatric Brain Tumor Consortium (PBTC), the New England Retinoblastoma Group and the Hodgkin Lymphoma Consortium.

Pediatric Epilepsy Research Lab: Kevin J. Staley, MD

The Pediatric Epilepsy Research Lab studies how neuronal ion transport and synaptic plasticity alter the spread of epileptic activity in neural networks.

Pediatric Psychopharmacology Clinical & Research Program

Our goal is to advance the well being of children and families afflicted with mental illness through clinical care, education and research.

Physics Research for Radiation Oncology

Research efforts are focused on developing radiation treatment techniques to optimize physical dose conformation to the tumor target volume and to increase the precision of the dose application.

Pillai Lab

"Research topics include: B cell Development and Lineage Commitment; A Novel Cell Surface Acetylation/Deacetylation Paradigm for Regulating Humoral Immunity and Development; Characterizing Peripheral Human B cells and B cells in Patients with Chronic Lymphocytic Leukemia"

Plastic Surgery Research Laboratory

The Plastic Surgery Research Laboratory conducts investigations into tissue engineering of cartilage, mechanisms of neural injury and regeneration, ischemia/reperfusion injury, and transplantation of vascularized limb tissues.

Preffer Lab

Of particular present interest are side populations [SP] cells, which are relatively rare cells found in both the circulation and bone marrow.

Program in Glomerular Disease

The MGH Program in Glomerular Disease is founded with the mission to advance understanding of the molecular mechanisms of urinary protein loss and associated kidney diseases.

Program in Membrane Biology

The MGH Program in Membrane Biology brings together a diverse group of investigators with a common interest in understanding how physiological signals regulate tissue and organ function at the cellular level.

Psychiatric Neuroscience

The Psychiatric Neuroscience Division is comprised of several programs, encompassing research, training and clinical services.

Psychiatric Neuroscience: Epidemiology Research

Epidemiology provides a public health perspective on mental health and mental illness in that it is concerned with psychiatric disorders in the general population.

Psychiatric Neuroscience: Gerontology Research

The Geriatric Neurobehavioral Clinic at Massachusetts General Hospital offers a multidisciplinary and individualized approach to the diagnosis of persons with memory disorders.

Psychiatric Neuroscience: Neurochemistry

Successfully studying novel chemotherapeutic agents for clinical trials in Alzheimer patients.

Psychiatric Neuroscience: Neurotherapeutics

The MGH Psychiatric Neurotherapeutics Program encompasses the clinical, research and training activities related to device-based treatments for psychiatric disorders.

Psychiatric Neuroscience: Post Traumatic Stress Disorder and Psychophysiology Lab

The laboratory's mission is to perform state-of-the-art psychobiological research into the assessment, pathophysiology, prevention, and treatment of post-traumatic stress disorder.

Psychiatric Neuroscience: Psychiatric and Neurodevelopment Genetics Unit

In addition to gaining more information about psychiatric disorders, we are interested in understanding how genes are passed on from generation to generation and also very interested in finding susceptibility genes.

Psychiatric Neuroscience: Psychiatric Neuroimaging

The MGH Psychiatric Neuroimaging Research Program focuses on a broad scope of research topics uniting many collaborators across neuroscience disciplines, and utilizing a full complement of neuroimaging technologies.

Psychotherapy Research Program

The Psychotherapy Research Program at Massachusetts General Hospital was formed in 1999 to study the process and outcome of psychotherapy empirically.

Radiation Oncology Biostatistics & Biomathematics

The Division of Biostatistics & Biomathematics supports research-oriented databases and data management needs for Radiation Oncology.

Rajagopal Lab

Our laboratory focuses on organ regeneration and the application of developmental biology to human disease. We focus on the lung as a model system since there is an abundance of respiratory diseases of unknown cause without cures.

Raje Lab

Research topics include: multiple myeloma; tumor microenvironment; bone disease and myeloma; novel therapies for multiple myeloma

Ramaswamy Lab

Research topics include: Cancer Genetics and Genomics; Progression; Invasion and Metastasis; Drug and Treatment Resistance; Computational Biology.

Ramaswamy Lab

Our major goal is to identify important cancer gene networks that are essential in human cancer metastasis and drug resistance, to guide the development and clinical use of new cancer drugs and diagnostics.

Reproductive Endocrine

Select a topic from this list to view a detailed description of the study:

Reproductive Endocrine Unit All Research

The Reproductive Endocrine Unit in the Endocrine Division at Massachusetts General Hospital hosts a broad-based clinical and basic scientific research program into the scientific basis of reproductive disorders in the human.

Rivera Lab

Our work focuses on the identification and characterization of pathways involved in Wilms tumor and kidney development.

Robert E. Gerszten, MD

The Gerszten Laboratory investigates the molecular basis of injury responses in cardiovascular disease.

Robert Wood Johnson Foundation

The Nursing Ambulatory to Hospital Transitions Program (NAHT) - 2 year award.

Rocco Lab

Research topics include: P63 mediators as targets in head and neck cancer

Rosenberg Lab

We focus on the immunology and pathogenesis of HIV infection with a particular interest in CD4+ T helper cells in persons with acute HIV and long-term non-progressive infection.

Sarcoma Molecular Biology Laboratory

The Orthopaedic Oncology Laboratory continues to seek factors that may serve as predictors of metastasis in malignant bone and soft tissue tumors both by molecular and biochemical studies and by flow cytometric analyses of DNA ploidy and cell cycle parameters.

Sarcomas & Soft Tissue Tumors Clinical Research

The Center for Sarcoma and Connective Tissue Oncology offers a truly multidisciplinary approach to care, including research and clinical trials conducted as part of one of the largest hospital-based programs in the nation.

Scadden Lab

The Scadden lab focuses on hematopoietic stem cells and their niche with the intent of developing new therapies for blood disorders and malignancies.

Schizophrenia Clinical & Research Program

The MGH Schizophrenia Program offers comprehensive diagnostic evaluations, consultations, treatment and opportunities to participate in research located at the main MGH campus and at the nearly Lindemann Mental Health Center.

Schmahmann, Jeremy D., MD - Laboratory for Neuroanatomy and Cerebellar Neurobiology

I am interested in the structure and function of the cerebellum, and in the cerebral and cerebellar roles in cognition and emotion. We perform neuroanatomical tract tracing studies in monkey; structural and functional MRI and PET in patients and controls; and we treat and study patients with ataxia and/or cognitive disorders.

Schmidt Lab

Research topics include: Cyclin D1

Schneeberger Lab

Our laboratory examines the molecular composition and regulation of tight junctions as they pertain to the permeability properties of the lung. A second major goal of our laboratory is to examine the biology of dendritic cells in the lung.

Schwarzschild, Michael A. - Molecular Neurobiology Laboratory

The Schwarzschild lab targets three purines—adenosine, caffeine and urate—in pursuit of improved therapy for Parkinson’s and related neurodegenerative diseases.

Settleman Lab

Research topics include: targeted therapies; signaling in cancer; PI3K signaling pathway; EGFR inhibitors in cancer; sensitivity and resistance to targeted therapies

Sgroi Lab

My laboratory is currently focused on applying high-throughput DNA microarray and proteomic technologies as a means to predict the clinical behavior of human breast cancer in the setting of specific hormonal and chemotherapeutic regimens.

Sharma Lab

Research topics include: Targeted Anti-cancer Therapeutics on Epidermal Growth Factor Receptor (EGFR)

Shioda Lab

Research topics include: signaling of mammary epithelial cells

Skeletal Biology Research Center

The Skeletal Biology Research Center of the Department of Oral and Maxillofacial Surgery does pioneering work to apply advances is biomedical engineering, biomechanics, tissue engineering, and computer-aided surgical planning to the art of reconstruction or congenital and acquired facial deformities.

Smith Lab

Dr. Smith's research focuses primarily on immunology and transplantation, with emphasis on the transplantation pathology of the heart, kidney, and pancreatic islets.

Stem Cell Biology and Cellular Reprogramming Laboratory – Choi Laboratory

We study transcriptional regulation of gastrointestinal and hepatobiliary development and its application to regenerative medicine and cancer.

Stemmer-Rachamimov Lab

Our lab's research focuses on identifying the underlying molecular changes in the lesions and malformations associated with hereditary brain tumor syndromes (neurofibromatosis 1, neurofibromatosis 2, schwannomatosis and tuberous sclerosis), and the identification of activated pathways or events that lead to tumor progression.

Stoeckle Center Research

Current Stoeckle Center research initiatives focus on evaluating educational programs, tools and interventions to identify best clinical practices and the most effective ways to involve patients and families in shared decision-making.

Stone Lab

The laboratory is seeking to understand the biochemical processes resulting in atherosclerosis in order to combat this pervasive disease.

Stroke Service Research

Clinical stroke research is critical to the prevention and treatment of this disabling disease. Our research may take the form of clinical trials, or studies that follow patients over time.

Supko Lab

Research topics include: pharmacokinetic studies of new anticancer agents

Sweetser Lab

Research topics include: leukemia; AML; Groucho/TLE; mouse models; stem cells

Tanabe Lab

Research topics include: hepatobiliary cancer; Epidermal Growth Factor and hepatocellular carcinoma

Tanzi Lab - Genetics and Aging Unit

Dr. Rudolph Tanzi is carrying out genome-wide association screens to identify novel genes associated with AD and autism spectrum disorders.

Tearney Lab

My research interests are primarily focused on the development and validation of non-invasive, high-resolution optical imaging methods for disease diagnosis.

Terry Means, PhD

The Means Laboratory combines molecular biology, cellular biology, and genetics to understand the molecular and cellular mechanisms of inflammation and host defense.

Thayer Lab

The principal focus of our research is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic cancer, specifically the contribution of developmental genes.

The Alan and Lorraine Bressler Clinical and Research Program for Autism Spectrum Disorders

To improve the clinical care of children and adults with autism spectrum disorders, to advance the education of patients, families and service providers about these conditions, and to expand the scientific understanding of these disorders.

The Center for Law, Brain and Behavior

The Center for Law, Brain and Behavior brings together faculty and research facilities from diverse neuroscientific disciplines in order to clarify the appropriate use of psychiatric and neuroscientific technologies.

The Program in Nutritional Metabolism, Massachusetts General Hospital

The MGH Program in Nutritional Metabolism was formed under the Direction of Dr. Steven Grinspoon, a recognized expert in the nutritional regulation of pituitary function and the metabolic consequences of obesity and fat redistribution.

Thoracic Cancers Clinical Research

Lung cancer is the leading cause of cancer-related mortality in the United States. Despite great advances in the understanding of lung cancer biology, only 15% of patients are alive five years after diagnosis. The research program of the Center for Thoracic Cancers is a multifaceted effort designed to understand thoracic cancer biology, discover novel agents and improve treatment.

Thorsten R. Mempel, MD, PhD

The Mempel Laboratory investigates cell migration and intercellular communction in the adaptive immune system through direct dynamic in vivo visualization of immune cell behavior using multiphoton intravital microscopy in mice.

Tic Disorders

The Tic Disorders Clinic & Research Unit at the Massachusetts General Hospital/Harvard Medical School is one of only a few clinics in the United States specializing in the treatment and research of Tourette Syndrome (TS) and related tic disorders.

Tissue Engineering & Organ Fabrication Lab

The Tissue Engineering & Organ Fabrication Lab is designing and building new, living tissues and organs for patients. We have worked in the field of Tissue Engineering since 1985. We have designed and tested 27 tissues of the body including vital organs needed for transplantation.

TRANSCEND Research Laboratory, Martha Herbert, MD, PhD

TRANSCEND. Treatment Research and NeuroSCience Evaluation of Neurodevelopmental Disorders.

Translational Center Investigating Prescription Drug Abuse (MIDA)

MIDA is an interdisiplinary collaborative center for the purpose of basic science and clinical research of prescription drug abuse.

Transplantation Biology Research Center

The mission of the TBRC is to understand the basic immunologic mechanisms through which specific tolerance can be induced for organ and bone marrow transplant recipients, and to find creative new means of dealing with the shortage of available organs.

Trauma Research Laboratory

Research at the Trauma Research Laboratory targets critical aspects of early trauma care, focusing on clearly defined high-impact goals.

Tsao Lab

The overall goal of my research effort is to better understand the genetic basis of melanoma formation and the clinical realization of these molecular events.

Type 2 Diabetes Laboratory Research

The Diabetes Lab focuses on studies relating to insulin resistance in Diabetic patients.

United States Critical Illness and Injury Trials Group (USCIITG)

The USCIIT Group aims to establish a critical care research consortium for the United States.

Urology Research Lab

The aim of the Urology Research Lab is to reduce the burden on our patients by studying the basic mechanisms that are responsible for some of the common urologic diseases.

Urology Research Lab

The Urology Research Lab studies the molecular basis of urologic tumors, including cancers of the prostate, bladder and kidney.

Vacanti Lab

Our tissue engineering research lies at the interface between basic and translation work where we focus on regenerating or replacing diseased organs and tissues. Combining the disciplines of medicine, molecular and developmental biology, material science, and biotechnology, we have applied tissue engineering principles to design and engineer replacement tissues.

Vascular Biology Research Laboratory

The Vascular Surgery Research Laboratory is involved in experimental strategies geared towards understanding the pathophysiology of intimal hyperplasia and ischemia reperfusion injury. We are also involved in the development of novel clinically relevant experimental therapies to treat and/or prevent both of these complex problems.

Vasudevan Lab

Research topics include: non-coding RNAs, microRNAs, AU-rich elements, Translation, Cytokines, VEGF, oocytes, cell cycle, quiescence

Warshaw Lab

The principal focus of our research is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic cancer, specifically the contribution of developmental genes.

Wayne Shreffler, MD, PhD

The Shreffler Laboratory is interested in the mechanisms regulating both primary sensitization and the subsequent balance between immune progression or regulation that determines either clinical sensitivity or tolerance to mucosal allergens.

Whetstine Lab

Research topics include: histone demethylase; chromatin; C. elegans; transcription; epigenetics; JMJC; HDAC

Wilbur Lab

Gynecologic cytopathology, computerization in pathology, translation of molecular methods

Willers Lab

Research topics include: lung cancer; radiation; EGFR; molecular targeting; DNA repair

Women's Mental Health

Please see our website for Women’s Mental Health, a perinatal and reproductive psychiatry information center, at www.womensmentalhealth.org

Wu Lab

We are in the process of identifying molecular and genetic changes of urologic cancers that correlate with the cancer disease behaviors, both clinically and pathologically. The long-term goal of these studies is to develop new diagnostic methods and therapeutic regiments for these cancers.

Xavier Laboratory

The primary research goal of the Xavier Laboratory at Massachusetts General Hospital is to discover and understand the function of important mediators and effectors involved in both the innate and adaptive immune systems. Of particular interest are the cellular components and regulatory networks that interact dynamically within temporal, spatial and pathophysiological contexts of innate immunity. 1. Systems biology of innate and adaptive immunity 2. Functional mapping of pathways associated with Crohn's disease, ulcerative colitis and diabetes 3. Genetics of Cron's disease, celiac disease and ulcerative colitis

Xu Lab

Research topics include: tumor angiogenesis and metastasis; tumor microenvironment

Yagi Lab

Informatics and digital imaging management

Yajnik Lab

My principal interest is to understand the molecular basis of cancer progression.

Zou Lab

Research topics include: DNA damage response; DNA damage checkpoint; checkpoint signaling; checkpoint activation; genomic instability

Zukerberg Lab

We have recently cloned a novel protein, Cables, which maps to human chromosome 18q and inhibits growth of cells in culture and tumor formation in nude mice.

Biostatistics Unit

The Biostatistics Center maintains a combined research and collaborative program that focuses on the development and application of quantitative methods relevant to cancer.

Cancer Pharmacology Core

The Cancer Pharmacology Core provides DF/HCC investigators with the necessary expertise and resources to design and undertake pharmacokinetic studies in the context of phase I and phase II clinical trials, and preclinical investigations.

Cardiovascular Imaging Core Lab

The Cardiovascular Imaging Core Lab at Massachusetts General Hospital is an independent facility dedicated to providing the highest quality services to the cardiovascular imaging community.

CBRC Cores

Overview of CBRC Cores. Please follow the link below for the main MGH Cores page

Center for Cancer Risk Assessment

The Center for Cancer Risk Assessment (CCRA) is devoted to the integration of molecular genetics and the clinical study of cancer predisposition. The Center has both laboratory and clinical components.

Center for Molecular Therapeutics

The Center for Molecular Therapeutics is actively investigating better ways to match individual cancer patients with particular targeted drug therapies in order to maximize the likelihood of a clinical response.

Center for Outcomes Research

Our research focuses on evaluating the impact of cancer and its treatment on patients, helping patients make better, more informed treatment decisions, and assessing and improving patient-centered cancer care.

Circulating Tumor Cell Center

The goal of our center is to transform the CTC-Chip into a robust technology that will allow detailed studies across multiple different types of cancer.

Circulating Tumor Cell Center

The goal of our center is to transform the CTC-Chip into a robust technology that will allow detailed studies across multiple different types of cancer.

Clinical Laboratory Research Core (CLR)

The Pathology Service CLR performs full service clinical laboratory testing and specimen banking to support research at MGH and Partners affiliated organizations. Testing for investigators outside of Partners can be arranged on an individual basis.

Functional Genomics

Genome-wide RNAi libraries available at the Broad Institute

hESC Core Facility

The purpose of the human embryonic stem cell (hESC) Core Facility is to provide an institutional resource for hESC research at Massachusetts General Hospital.

HSCI-CRM Flow Cytometry Core Facility

Offers custom-built instrumentation for cell sorting and data analysis.

Humanized Mouse Model of HIV Infection

This program investigates HIV pathogenesis and evaluates anti-HIV preventive and therapeutic interventions, in an improved humanized mouse model capable of generating HIV-specific human cellular and humoral immune responses.

Institute for Healthcare Policy

The Institute for Health Policy (IHP) is dedicated to conducting world-class research on the leading health issues.

Intravital Microscopy Lab

The CIID Intravital Microscopy Lab is dedicated to the dynamic visualization of cellular processes in vivo in small animals using multiphoton excitation fluorescence microscopy.

Light Microscopy and Image Analysis Core

Includes state-of-the art Nikon upright (80i) and inverted (TE2000-U) microscopes.

Mental Health & The Media

The mission of the Center for Mental Health and Media is to save lives, comfort and educate families, and to change the public's outdated and inaccurate perceptions of the nature, causes and treatment of mental illness.

Metabolomics and Proteomics

A targeted liquid chromatography-mass spectrometry-based metabolomics platform in collaboration with the Broad Institute.

MGH Tissue Repository

The goal of the Massachusetts General Hospital Tissue Repository is to collect human tumor surgical specimens for distribution to researchers in the Massachusetts General Hospitals scientific community, and to the broader biomedical science community as well. Tumor specimens are now available for distribution to researchers.

Molecular Profiling Laboratory

The Molecular Profiling Laboratory (MPL) is one of the Cancer Center research centers that provide technological support to Cancer Center investigators.

Mood & Anxiety Disorders Institute (MADI)

The Center translates the latest research advances into practical information to help people work with their doctors toward the most accurate diagnosis and best possible treatment results.

Mouse Models

The Luster lab has expertise in mouse models of disease and in the generation of genetically modified knockout, transgenic and reporter mice to study immune cell function in vivo.

Neurogenetics DNA Diagnostic Laboratory

The Neurogenetics DNA Diagnostic Laboratory at Massachusetts General Hospital conducts standard-setting molecular DNA diagnostic testing for over 25 rare neurodegenerative disorders.

Pallative Care

The Palliative Care Service, in conjunction with the Harvard Medical School Center for Palliative Care, continues to focus research on innovative projects to promote education in end-of life care for health care professionals.

Phase I Clinical Trials Program

Basic research is necessary to achieve an understanding of the normal and pathological state, but cannot, by itself, put new knowledge to useful applications. The bridge to application is created by the development of diagnostic tests, new drugs or treatment approaches that allow an intervention in patients.

Psychiatric Oncology

As a collaboration between the Department of Psychiatry, consistently rated the best program in the US, and the Cancer Center, we are able to complement the research on cancer treatments by focusing on the psychological and behavioral aspects of cancer.

Specialized Histopathology Services

Tissue analysis is critical to validation and evaluation of animal models of human cancer, and human cancer tissues serve as the "operating system" for translational research.

Tetramer Resource Lab

The Tetramer Resource Lab generates fluorescently labeled peptide:MHC multimers for the purpose of detecting polyclonal populations of antigen-specific T cells.

The Analytical and Quantitative Cytology Core Facility

The Analytical and Quantitative Cytology Core Facility offers services and equipment to perform most flow cytometric assays.

The Genomics of Drug Sensitivity (GDS)

Anti-cancer drugs are screened against a large collection (>1000) cancer cell lines representative of many different malignancies to discover links between genotypes and drug response.

Tobacco Research and Treatment Center

The Tobacco Research and Treatment Center's clinical research aims to identify effective tobacco treatment strategies and adapt them for the smokers who come to the health care setting.

Translational Research Laboratory

A laboratory dedicated to fostering personalized cancer patient care, through development and implementation of innovative tumor genotyping technologies and collaborative clinical and translational research studies.

Tumor Imaging Metrics

The mission of the Tumor Imaging Metrics Core (TIMC) is to provide standardized, consistent, longitudinal radiological measurements to evaluate therapeutic response for DF/HCC clinical trials.